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APOE & MTHFR Genetic Test from RxHomeTest

Labbrary Test GradeStrong
Your Fit Score
Not calculated

Answer five questions to see how this panel matches your goals, budget, collection preferences, access, and support needs.

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Labbrary's review, Fit Score, and basic comparison are free. The provider's panel, shipping, collection, clinician review, and other services are separate. About 2 minutes. No account required.

An at-home saliva test analyzing ApoE, MTHFR, and KLOTHO gene variants tied to cognitive aging, with results delivered within days of the lab receiving the sample.

Current price
$129.99
Sample
Saliva
Turnaround
5 to 7 days
Access
At Home, Mail In, Order Online
Evidence & Key Facts
Source collectedLast source check September 17, 2026

Evidence basis. This named result reflects the sources and verification evidence listed on this page as of the date shown.

Best for

Brain Health, Genetic Risk

Standout strength

SNP-level transparency: the exact APOE, MTHFR, and KLOTHO markers are disclosed before purchase.

Important watch-out

MTHFR and KLOTHO are secondary to APOE for Alzheimer's risk - most of the Alzheimer's signal comes from the APOE result alone.

APOE & MTHFR Genetic Test from RxHomeTest
Labbrary Test GradeStrong
Your Fit Score
Not calculated

Answer five questions to see how this panel matches your goals, budget, collection preferences, access, and support needs.

Calculate my fit

Labbrary's review, Fit Score, and basic comparison are free. The provider's panel, shipping, collection, clinician review, and other services are separate. About 2 minutes. No account required.

An at-home saliva test analyzing ApoE, MTHFR, and KLOTHO gene variants tied to cognitive aging, with results delivered within days of the lab receiving the sample.

Current price
$129.99
Sample
Saliva
Turnaround
5 to 7 days
Access
At Home, Mail In, Order Online
Evidence & Key Facts
Source collectedLast source check September 17, 2026

Evidence basis. This named result reflects the sources and verification evidence listed on this page as of the date shown.

Best for

Brain Health, Genetic Risk

Standout strength

SNP-level transparency: the exact APOE, MTHFR, and KLOTHO markers are disclosed before purchase.

Important watch-out

MTHFR and KLOTHO are secondary to APOE for Alzheimer's risk - most of the Alzheimer's signal comes from the APOE result alone.

Labbrary+

The Test Grade. The Reason Behind It.

Strong overall documentation and usefulness, with limitations worth comparing before purchase.

A lower grade does not mean a panel is a bad personal fit. Your Fit Score can be higher when its purpose, price, sample, access, or support matches what you need.

Explore the Full Methodology
Labbrary Test GradeStrong

Next step

Check the panel or research the provider

Prices, availability, and ordering requirements can change. Confirm the current details before purchasing.

View Exact Panel on Provider SiteView RxHomeTest profile

Scope, both directions

Inside the Panel. Beyond the Name.

Named measurements

  • APOE genotype (Apolipoprotein E; amplified sites rs429358, rs7412)
  • MTHFR (Methylenetetrahydrofolate reductase; rs1801133, rs1801131)
  • KLOTHO gene marker (markers 806, 888, 840)

Measured categories and focus areas

  • Genetics
  • Brain Health
  • Genetic Risk

Important limits and omissions

Additional exclusions have not been confirmed for this test. Compare the named biomarkers with the markers you want before ordering.

The full breakdown

Eight Dimensions.
One Named Result.

Open any row for the reasoning and evidence behind the named result.

The page discloses the exact markers tested - APOE rs429358 and rs7412, MTHFR rs1801133 and rs1801131, and KLOTHO markers 806, 888, and 840 - and states testing is performed in CLIA-certified laboratories. The assay method and analytical performance figures are not published.

The APOE result is directly relevant to Alzheimer's genetic risk. MTHFR and KLOTHO relate to folate metabolism and aging biology, which are secondary to APOE for Alzheimer's risk, so part of the panel sits outside the core Alzheimer's question.

Three genes are covered: APOE, MTHFR, and KLOTHO. The panel includes no amyloid or tau blood biomarkers and no cognitive performance measures, so it assesses inherited risk factors only.

The price is clearly stated at $129.99 on sale from $199.99, with free shipping both ways and no membership or insurance processing. HSA or FSA eligibility is not addressed.

The report marks and explains each genotype in easy-to-understand language. It offers no medical recommendations and advises consulting a doctor, which is appropriate framing for a direct-to-consumer genetic risk test.

SNP-level marker detail, the sale price, the 5 to 7 business day turnaround, the New York and New Jersey exclusions, and a full sample and data retention schedule are all disclosed on the page. Assay performance figures remain unpublished.

The at-home saliva swab kit arrives in 3 to 5 business days with free return shipping, and results follow within 5 to 7 business days of lab receipt. The test is unavailable in New York and New Jersey.

The page claims HIPAA compliance and publishes a retention schedule: samples kept 2 weeks, extracted DNA 3 months, data retained a minimum of 2 years. Third-party sharing terms beyond that are not fully detailed.

Under the hood

Follow the Evidence.

Every published claim should trace to a dated source. Missing evidence remains visible instead of being filled with assumptions.

Source 1Recorded for this record. Last source check September 17, 2026.View source

True total cost

The Price. Plus the Details.

Pricing for APOE & MTHFR Genetic Test
ItemCurrent disclosed priceNote
Panel$129.99Verify the checkout total, shipping, and collection fees before ordering.
Checkout feesNot confirmedLabbrary hasn't recorded this seller's order, draw or physician fees yet. Check the total at checkout.
HSA/FSA paymentNot confirmedHSA/FSA payment eligibility has not been confirmed from provider documentation.
Optional servicesNot confirmedClinician review, subscriptions, and retesting discounts are listed only when documented.

Price status. This record shows disclosed pricing. Checkout costs can change and should be verified before purchase.

Your data

Your Data. Your Questions.

Privacy details are scored only when source documentation is available. Unconfirmed retention, deletion, research use, or marketing practices remain unconfirmed.

Reading the labels

What Has Been Checked?

Source collected

Evidence labels stay separate from the Test Grade. They show how much source support exists for the evaluation.

The balance

The Strengths. The Tradeoffs.

Strengths

  • SNP-level transparency: the exact APOE, MTHFR, and KLOTHO markers are disclosed before purchase.
  • Fastest turnaround of the at-home set: 5-7 business days after the lab receives the sample.
  • $129.99 sale price with free shipping both ways.
  • Published sample and data retention schedule (sample 2 weeks, DNA 3 months, data minimum 2 years).

Watch-outs

  • MTHFR and KLOTHO are secondary to APOE for Alzheimer's risk - most of the Alzheimer's signal comes from the APOE result alone.
  • Includes no amyloid or tau blood biomarkers.
  • Assay performance figures are not published.
  • Not available in New York or New Jersey.

Take it with you

The Test Truth Card

The key facts from this review in one compact card.

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Verification History

September 17, 2026Recorded source date.Source collected

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